Pterostilbene Supreme
DESCRIPTION
Pterostilbene Supreme, by Douglas
Laboratories, provides pterostilbene, a
methylated resveratrol that is naturally occurring
in berries. This formula also contains
resveratrol, curcumin and vitamin D3 which can
function synergistically with ptersostilbene to
support healthy aging. †
FUNCTIONS
Pterostilbene, a methylated form of resveratrol is
considered the next generation of resveratrol.
Pterostilbene has advantages over resveratrol:
superior biological activity, better oral
bioavailability, and slower metabolism in the
body.
pTeroPureTM pterostilbene is a nature identical
form of trans-pterostilbene, a stilbene found in
certain berries. The enhanced activity of
pterostilbene compared to resveratrol may, in
part, be explained by structural differences.
Pterostilbene with two methoxy groups and one
hydroxyl group has greater lipophilicity and a
higher potential for cellular uptake than
resveratrol, which has three hydroxyl groups.
Pterostilbene showed strong inhibitory activity,
much more than resveratrol, against a particular
form of cytochrome P450.
Researchers have suggested that these two
compounds also work synergistically,
supporting the theory that a combination of
pterostilbene and resveratrol in a formulation
may be more effective than using these
ingredients separately. Both pterostilbene and
resveratrol support mitochondrial function and
healthy aging by activating SIRT1, one of the
key enzymes of the sirtuin family. Sirtuins, a
class of proteins, have been implicated in
influencing aging and regulating transcription,
apoptosis and stress resistance, as well as energy
efficiency and alertness during low-calorie situations. † Pterostilbene also supports
cardiovascular health; results from in vitro
studies showed that pterostilbene acts as a
PPARR agonist and may be a more effective
PPARR agonist and hypolipidemic agent than
resveratrol. In vivo studies demonstrate that
pterostilbene possesses lipid and glucose
lowering effects. † Pterostilbene Supreme also
contains ResvidaTM, a pure resveratrol clinically
studied for its safety. ResvidaTM resveratrol is
unique as it is not a plant extract and is not
derived from plant sources, therefore presents no
risk for contamination with pesticides and other
potentially unwanted compounds. Studies
indicate resveratrol may be supportive in
maintaining the normal aging process by helping
to prevent free radical damage that can lead to
premature aging of cells. †
Studies have shown that curcumin, a naturally
occurring group of compounds from turmeric,
function as powerful antioxidants and can help
support neurological and cardiovascular
function.† Since curcumin exhibits poor oral
absorption in the body, Douglas Labs has chosen
a highly bioavailable curcumin called
MERIVA®. Pharmacokinetic comparison
studies have shown MERIVA® to have up to a
20-fold improvement in bioavailability versus
the standard 95% turmeric extracts due to
proprietary PHYTOSOME technology which
increases hydrolytic stability.
Vitamin D, curcumin and
resveratrol/pterostilbene share many common
targets and points of overlap in gene regulation,
signal transduction and therapeutic effects. The
nature of this overlap suggests synergy upon
combination, potentially leading to an influence
on inflammatory and cardio-protective
pathways.
Japanese wasabi with a specially standardized
broccoli sprout concentrate and organic pomegranate extract are added to this formula to
support the body’s natural antioxidant and
detoxification processes. † Sulforaphane, an ITC
found in broccoli, has been found to
significantly increase the activity of
detoxification enzymes (cytochrome P450).
INDICATIONS
Pterostilbene Supreme may be a useful
supplement for individuals wishing to consume
a powerful combination of antioxidants and
vitamin D for cardiovascular health or longevity
support.
REFERENCES
Paul S, Rimando AM, Lee HJ, Ji Y, Reddy BS and Suh N. Antiinflammatory
action of pterostilbene is mediated through the p38
mitogen-activated protein kinase pathway in colon cancer cells.
Cancer Prev. Res. 2, 650 (2009)
Rimando AM, Cuendet M, Desmarchelier C, Mehta RG, Pezzuto
JM, and Duke SO. Cancer chemopreventive and antioxidant
activities of pterostilbene, a naturally occurring analogue of
resveratrol. J. Agric. Food Chem. 50, 3453 (2002)
Rimando AM, Nagmani R, Feller DR, Yokoyama W.
Pterostilbene, a new agonist for the peroxisome proliferatoractivated
receptor alpha-isoform, lowers plasma lipoproteins and
cholesterol in hypercholesterolemic hamsters. J Agric Food Chem.
2005 May 4;53(9):3403-7.
Izet M. Kapetanovic, Miguel Muzzio, Zhihua Huang, Thomas N.
Thompson, David L. McCormick. Pharmacokinetics, oral
bioavailability, and metabolic profile of resveratrol and its
dimethylether analog, pterostilbene, in rats. Cancer Chemother
Pharmacol. 2010. Nov 30.
Joseph JA, Fisher DR, Cheng V, Rimando AM, and Shukitt-Hale
B. Cellular and behavioral effects of stilbene resveratrol analogues:
implications for reducing the deleterious effects of aging. J. Agric.
Food Chem. 56, 10544 (2008)
Pari L, Satheesh MA. Effect of pterostilbene on hepatic key
enzymes of glucose metabolism in streptozotocin and nicotinamide
induced diabetic rats. Life Sci. 79, 641 (2006)
Paul S, Decastro A, Lee HJ, Smolarek AK, So JY, Simi B, Wang
CX, Zhou R, Rimando AM, Suh N
Dietary intake of pterostilbene, a constituent of blueberries,
inhibits the {beta}catenin/p65 downstream signaling pathway and
colon carcinogenesis in rats. Carcinogenesis, 31(7), 1272 (2010)
Lagouge M, Argmann C, GerhartHines
Z, Meziane H, Lerin C, Daussin F, Messadeq N, Milne J, Lambert
P, Elliott P, Geny B, Laakso M, Puigserver P, Auwerx J.
Resveratrol improves mitochondrial function and protects against
metabolic disease by activating SIRT1 and PGC1alpha Cell 127,
1109 (2006)
Anand, P., et al. Bioavailability of Curcumin: Problems and
Promises. Mol. Pharmaceutics: 2007, 4(6), pp. 807-818.
Marczylo T., Verschoyle R., Cooke D., Morazzoni P., Steward W.,
Gescher A. Comparison of systemic availability of curcumin with
that of curcumin formulated with phosphatidylcholine. Chemother.
Pharmacol. 2007, 60, 171-177.
Rivera L, Morón R, Zarzuelo A, Galisteo M. Long-term resveratrol
pressure in obese Zucker rats. Biochem Pharmacol. 2008, Dec 3.
Maroon, Joseph. The Longevity Factor: How Resveratrol and Red
Wine Activate Genes for a Longer and Healthier Life. Atria, 2008.
ISBN-10: 141655107
Wietzke JA, Welsh J. Phytoestrogen regulation of a Vitamin D3
receptor promoter and 1,25-dihydroxyvitamin D3 actions in human
breast cancer cells. J Steroid Biochem Mol Biol. 2003 Feb;84(2-
3):149-57.
Ingredients:
Serving Size: 2 tablets
Servings Per Container: 45
Amount Per Serving
Vitamin A ...1000 IU
(as Vitamin A Palmitate)
Vitamin C ...500mg
Thiamine ...10mg
Riboflavin ...10mg
Niacinamide ...10mg
Vitamin B-6 ...50mg
(as Pyridoxine HCI)
Folic Acid ...200mcg
Vitamin B-12 ...50mcg
Pantothenic Acid ...50mg
(as Calcium Pantothenate)
Calcium ...150mg
(from Calcium Aspartate Complex)
Magnesium ...75mg
(from Magnesium Aspartate Complex)
Zinc ...75mg
(from Zinc Aspartate Complex)
Manganese ...150mg
(from Manganese Aspartate Complex)
Potassium ...75mg
(from Potassium Aspartate Complex)
Aspartic Acid ...50mg*
Bioflavonoids ...250mg*
Bromelain ...200mg*
(Enteric Coated)
Trypsin ...100mg*
(Enteric Coated)
Chymotrypsin ...200mcg*
(Enteric Coated)
Glucosamine Sulfate ...125mg*
(from crab and shrimp)
Papain ...100mg*
(Enteric Coated)
Bovine Cartilage ...100mg*
Pepsin (1:3000) ...60mg*
Raw Veal Bone ...50mg*
Hesperidin Complex ...50mg*
Rutin ...50mg*
Proprietary Blend ...25mg*
Shave Grass (aerial parts), Valerian (root), Passion Flower (aerial parts), Passiflora incarnata, Dried Pineapple Juice.
* Daily Value not established
Contains:
Cellulose, Vegetable Stearate, Silica
Does Not Contain:
Yeast, Wheat Gluten, Soy Protein, Milk/Dairy, Corn, Sodium, Sugar, Starch, Artificial Coloring, Preservatives, Flavoring
Dosage:
As a dietary supplement, adults take 2 tablets 3 times daily, preferably on an empty stomach, or as directed by your healthcare professional.
WARNINGS:
KEEP OUT OF REACH OF CHILDREN.
For optimal storage conditions, store in a cool, dry place.
(59º-77ºF/15º-25ºC)
(35-65% relative humidity)
Tamper resistant package, do not use if outer seal is missing.
If you have an allergy to shellfish (including crab and shrimp) you should not use this product.
